Thermo Fisher Scientific NCF4 Monoclonal Antibody (OTI1A7), TrueMAB
Human NCF4 단백질을 인식하는 Mouse IgG1 단클론 항체. Western blot 검증 완료. 액상 형태, 1 mg/mL 농도. Affinity chromatography로 정제되었으며 PBS/BSA/glycerol buffer에 보존. 연구용 전용 시약.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A7 |
| Immunogen | Full length human recombinant protein of human NCF4 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by the NCF4 gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense.
This protein is preferentially expressed in cells of myeloid lineage and interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox).
Upon cell stimulation, the complex interacts with the small G protein RAC1 and translocates to the membrane, activating flavocytochrome b—the membrane-integrated catalytic core of the enzyme system.
The PX domain binds phospholipid products of PI(3) kinase, suggesting a role in PI(3) kinase-mediated signaling. Phosphorylation of this protein negatively regulates enzyme activity.
Alternatively spliced transcript variants encoding distinct isoforms have been observed.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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