Thermo Fisher Scientific NCF4 Monoclonal Antibody (OTI1A7), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Target Information

The protein encoded by the NCF4 gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense.
This protein is preferentially expressed in cells of myeloid lineage and interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox).
Upon cell stimulation, the complex interacts with the small G protein RAC1 and translocates to the membrane, activating flavocytochrome b—the membrane-integrated catalytic core of the enzyme system.
The PX domain binds phospholipid products of PI(3) kinase, suggesting a role in PI(3) kinase-mediated signaling. Phosphorylation of this protein negatively regulates enzyme activity.
Alternatively spliced transcript variants encoding distinct isoforms have been observed.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.