Thermo Fisher Scientific Phospho-PAK4/6/7 (Ser474, Ser602, Ser560) Polyclonal Antibody
PAK4/6/7 단백질의 인산화 상태(Ser474, Ser602, Ser560)를 검출하는 Thermo Fisher Scientific의 폴리클로날 항체로, Western blot에 적합합니다. Rabbit IgG 기반으로 항원 친화 크로마토그래피 정제, 액상 형태이며 -20°C 보관.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Publications: View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Guinea pig, Human, Mouse, Pig |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide corresponding to residues surrounding pSer474 of human PAK4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES (pH 7.5), 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984818 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with phosphorylated PAK1, PAK2, or PAK3.
Target Information
PAK4 is highly expressed in prostate, testis, and colon. It interacts tightly with GTP-bound CDC42 and weakly with RAC, and it phosphorylates and autophosphorylates while activating the JNK pathway.
PAK5 contains a CDC42/Rac1 interactive binding (CRIB) motif at the N-terminus and a Ste20-like kinase domain at the C-terminus. It preferentially binds CDC42 in the presence of GTP, with the CRIB motif essential for this interaction.
PAK6 cotranslocates into the nucleus with androgen receptor in response to androgen, playing a role in male sexual differentiation and development. It is activated by MAP kinase 6 and p38 MAP kinase, suggesting involvement in stress-related cellular responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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