Thermo Fisher Scientific Anthrax Protective Antigen Polyclonal Antibody
Bacillus anthracis 보호 항원(PA)을 인식하는 토끼 폴리클로날 항체. Western blot에 적합하며, 합성 펩타이드(aa 186-192)로 면역화됨. 비결합형 액상 형태로 제공되며, 보존제 없음. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bacteria |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptides corresponding to amino acids 186–192 of the Anthrax PA protein (approx. 83 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not Determined |
| Storage Buffer | Whole serum, PBS |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1070416 |
Product Specific Information
Suggested positive control: PA recombinant protein.
Target Information
Anthrax infection is initiated by inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF).
PA binds to two related proteins on the cell surface, termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2). Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF; the resulting complex is endocytosed, allowing translocation of LF and EF into the cytoplasm. These toxins can cause rapid cell death and often organismal death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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