Thermo Fisher Scientific ADORA1 Polyclonal Antibody
ADORA1 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, Human, Mouse, Rat 반응성을 가집니다. Protein A로 정제된 1 mg/mL 액상 항체로 연구용에 적합합니다.
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Thermo Fisher Scientific ADORA1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human ADORA1, amino acids 151–250 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical, and pharmacological analyses have identified four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates receptor subtype-specific physiological processes such as cardiac rate regulation, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission.
The A1 adenosine receptor (A1AR) is a glycoprotein that activates Gi and Go proteins. In intact cells, A1AR activation causes pertussis toxin-sensitive inhibition of adenylyl cyclase and may stimulate phospholipase C, mobilizing intracellular calcium. Activation of potassium channels by A1AR influences cardiovascular function. A1AR is highly expressed in brain regions (cerebellum, hippocampus, thalamus, cortex) and spinal cord, modulating neurotransmitter release. In white adipocytes, A1AR inhibits lipolysis and stimulates glucose uptake. It is also expressed in kidney and testis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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