Thermo Fisher Scientific E2F6 Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1.0 µg/mL

Product Specifications

Product Specific Information

This target displays homology in the following species:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 85%; Rat: 93%

Target Information

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and in the action of tumor suppressor proteins. They are also targets of transforming proteins of small DNA tumor viruses.
Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain (for interaction with DP proteins), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain embedded within the transactivation domain.
The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and acts as an inhibitor of E2F-dependent transcription. The protein is part of a multimeric complex containing a histone methyltransferase and the transcription factors Mga and Max.
Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.