Thermo Fisher Scientific Mucolipin 1 Polyclonal Antibody
Mucolipin 1 단백질 검출용 Rabbit Polyclonal 항체로, WB 및 IHC에 최적화된 시약입니다. Human, Mouse, Rat 반응성이 있으며, 합성 펩타이드 항원을 기반으로 제작되었습니다. 연구용으로만 사용되며, MLIV 관련 연구에 유용합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | - |
| Immunohistochemistry (IHC) | 1:1,000–1:3,000 | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from mouse Mucolipin 1 conjugated to blue carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in human, monkey, and rat.
Specificity of this antibody: Mucolipin 1, isoforms 1 and 2.
Target Information
Defects in Mucolipin-1 are the cause of mucolipidosis type IV (MLIV), also known as sialolipidosis.
MLIV is an autosomal recessive lysosomal storage disorder characterized by severe psychomotor retardation and ophthalmologic abnormalities, including corneal opacity, retinal degeneration, and strabismus.
Storage bodies of lipids and water-soluble substances are seen by electron microscopy in almost every cell type of the patients.
Most patients are unable to speak or walk independently and reach a maximal developmental level of 1–2 years.
All patients have constitutive achlorhydria associated with a secondary elevation of serum gastrin levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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