Thermo Fisher Scientific CATSPER1 Polyclonal Antibody
CATSPER1 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, 사람 시료에 반응합니다. IHC(P)에서 사용 가능하며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1:25–1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Fusion protein corresponding to residues near the C-terminal of human cation channel, sperm associated 1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.8 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2635825 |
Product Specific Information
The antibody detects endogenous levels of total CATSPER1 protein.
Target Information
Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction, and chemotaxis towards the oocyte.
Activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2.
The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers.
Sperm capacitation enhances the effect of progesterone by providing an additional negative shift. Also activated by the elevation of intracellular pH.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-50372_CATSPER1_Q8NEC5-1_Rabbit.svg)
(이미지: PA5-50372_CATSPER1_Q8NEC5-1_Rabbit_PDP.jpeg)
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