Thermo Fisher Scientific PARN Polyclonal Antibody
Human, Mouse, Rat 반응성을 가진 Rabbit Polyclonal Anti-PARN 항체. Western blot 및 IHC(Paraffin) 적용 가능. 항원 친화 크로마토그래피로 정제된 액상 형태. 장기 보관 시 -20°C에서 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PARN. Recombinant protein control fragment (Product #RP-89280). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645213 |
Product Specific Information
Immunogen sequence:
QEELNDAVGF SRVIHAIANS GKLVIGHNML LDVMHTVHQF YCPLPADLSE FKEMTTCVFP RLLDTKLMAS TQPFKDIINN TSLAELEKRL KETPFNPPKV ESAEGFPSYD
Highest antigen sequence identity to the following orthologs:
- Mouse: 95%
- Rat: 95%
Target Information
The protein encoded by this gene is a 3'-exoribonuclease, similar to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate and efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is involved in silencing certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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