Thermo Fisher Scientific ASGR1 Polyclonal Antibody
인간 ASGR1 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, PBS 버퍼(40% 글리세롤) 내 액상 형태로 제공. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human ASGR1. Recombinant protein control fragment (Product #RP-90285). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2638286 |
Product Specific Information
Immunogen sequence:
MTKEYQDLQH LDNEESDHHQ LRKGPPPPQP LLQRLCSGPR L
Antigen sequence identity:
Mouse – 76%, Rat – 76%
Target Information
The asialoglycoprotein receptor (ASGPR) is a transmembrane glycoprotein (42 kDa) that mediates binding, internalization, and degradation of extracellular glycoproteins with exposed terminal galactose residues. It is expressed on the hepatocyte surface in a polar manner—present on sinusoidal and lateral plasma membranes but not on the bile canalicular membrane. The hepatic ASGPR mediates endocytosis and degradation of serum proteins lacking terminal sialic residues.
The rat ASGPR consists of three subunits: RHL-1, RHL-2, and RHL-3. The monoclonal antibody 8D7 recognizes a subunit-specific epitope of RHL-1 and is cross-reactive with human ASGPR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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