Thermo Fisher Scientific FGFR1 Polyclonal Antibody
FGFR1 단백질을 인식하는 Thermo Fisher Scientific의 염소 유래 Polyclonal 항체. Western blot 및 IHC(P) 실험에 적합하며, 인간 반응성. 고순도 액상 형태로 제공되며, -20°C 보관. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.3–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–6 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CLPRHPAQLANGGLKR) corresponding to the C-terminus amino acids of FGFR1 (aa 806–822) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10982433 |
Product Specific Information
- Predicted to react with bovine and canine based on sequence homology.
- Tested in Peptide ELISA with antibody detection limit dilution of 1:32,000.
Target Information
FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors play key roles in:
- Mesoderm induction and patterning
- Cell growth and migration
- Organ formation and bone growth
FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic development and adulthood.
Mutations or aberrations in FGFR1 are implicated in several diseases, including:
- Pfeiffer syndrome (PS)
- Idiopathic hypogonadotropic hypogonadism (IHH)
- Kallmann syndrome type 2 (KAL2)
- Osteoglophonic dysplasia (OGD)
- Non-syndromic trigonocephaly
- Jackson-Weiss syndrome
- Antley-Bixler syndrome
Chromosomal abnormalities involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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