Thermo Fisher Scientific FGFR1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Predicted to react with bovine and canine based on sequence homology.
• Tested in Peptide ELISA with antibody detection limit dilution of 1:32,000.

Target Information

FGFR1 (also known as FLT2) is a member of the Fibroblast Growth Factor Receptor family (FGFR1–4), which are membrane-spanning tyrosine kinases serving as high-affinity receptors for 17 growth factors (FGF1–17).
These receptors play key roles in:

• Mesoderm induction and patterning
• Cell growth and migration
• Organ formation and bone growth

FGFR1 undergoes alternative splicing, producing multiple variants expressed differently during embryonic development and adulthood.
Mutations or aberrations in FGFR1 are implicated in several diseases, including:

• Pfeiffer syndrome (PS)
• Idiopathic hypogonadotropic hypogonadism (IHH)
• Kallmann syndrome type 2 (KAL2)
• Osteoglophonic dysplasia (OGD)
• Non-syndromic trigonocephaly
• Jackson-Weiss syndrome
• Antley-Bixler syndrome
  Chromosomal abnormalities involving FGFR1 are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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