Thermo Fisher Scientific HEF1 Monoclonal Antibody (14A11)

Thermo Fisher Scientific HEF1 Monoclonal Antibody (14A11)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Store vial at -20°C prior to opening.
• Aliquot contents and freeze at -20°C or below for extended storage.
• Avoid cycles of freezing and thawing.
• Centrifuge product if not completely clear after standing at room temperature.
• Stable for several weeks at 4°C as an undiluted liquid.
• Dilute only prior to immediate use.

Directed against human HEF1 protein. The product was purified from tissue culture supernatant by chromatography.
This antibody has only been tested on human cells, and reactivity against multiple isoforms is expected.
Reactivity against homologues from other sources is not known.
Specificity was determined by partial epitope mapping.

Target Information

HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation.
The Cas family of docking proteins are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases—two active targets for drug development.
HEF1 overproduction increases mRNA transcripts linked to motility, transformation, and invasiveness, including metalloproteinases, MLCK, p160ROCK, and ErbBi.
HEF1 overexpression mediates apoptosis in epithelial-derived cell lines such as MCF7 and HeLa.
Clinical studies have shown that overexpression of BCAR1 (p130Cas), a related protein, is associated with tamoxifen resistance, highlighting the importance of this family in cancer prognosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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