Thermo Fisher Scientific Bovine Transferrin Polyclonal Antibody, HRP

Thermo Fisher Scientific Bovine Transferrin Polyclonal Antibody, HRP

Applications and Tested Dilutions

Product Specifications

Target Information

Lactoferrin (LF) is an iron-binding glycoprotein composed of a single polypeptide chain (~80 kDa) folded into two homologous lobes, each capable of reversibly binding one ferric ion (Fe³⁺). LF is present in external fluids such as milk and mucosal secretions and forms a major component of neutrophil secondary granules.

It exhibits diverse biological functions including:

• Regulation of iron homeostasis
• Host defense against microbial infections
• Anti-inflammatory activity
• Control of cellular growth and differentiation
• Protection against cancer development and metastasis

LTF acts as a first-line defense against microbes by binding and removing Fe³⁺ from the environment. It also shows bactericidal and proteolytic activities, cleaving arginine-rich sequences in microbial proteins. Three isoforms (LTF-α, LTF-β, LTF-γ) have been identified, and LTF receptors are expressed in the gastrointestinal tract, macrophages, lymphocytes, neutrophils, platelets, and certain bacteria.

Additional Information

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.