Thermo Fisher Scientific PTCH Polyclonal Antibody
Thermo Fisher Scientific의 PTCH Polyclonal Antibody는 인간, 생쥐, 닭, 쥐 시료에서 PTCH 단백질 검출에 적합합니다. Western blot에 검증되었으며, 항원 친화 크로마토그래피로 정제되었습니다. 액상 형태로 제공되며, 2–8°C에서 단기 보관이 가능합니다.
- 판매단위
- pk
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Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2174042 |
Product Specific Information
PA1-4134 detects Patched (PTCH) in human samples.
It has been successfully used in Western blot procedures.
By Western blot, this antibody detects a ~158 kDa protein representing PTCH in fetal brain lysate.
The PA1-4134 immunogen is a synthetic peptide corresponding to residues K(269) K I N Y Q V D S W E(279) of mouse PTCH.
This sequence is 100% conserved in human, rat, and chicken PTCH, and is expected to cross-react with these samples.
Target Information
This gene encodes a member of the patched gene family.
The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins.
This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly.
Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full-length sequences and biological validity cannot be determined currently.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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