Thermo Fisher Scientific IFI16 Monoclonal Antibody (2C2)
Human IFI16 단백질을 인식하는 Mouse 단일클론 항체로, Western blot 및 ELISA에 적합. Unconjugated 형태의 액상 제품이며, -20°C에서 보관. 세포 내 IFI16 관련 면역반응 및 전사 조절 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2C2 |
| Immunogen | IFI16 (AAH17059, 630–729 a.a.) partial recombinant protein with GST tag. MW of GST tag alone: 26 kDa |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
FVNGVFEVHK KNVRGEFTYY EIQDNTGKME VVVHGRLTTI NCEEGDKLKL TCFELAPKSG NTGELRSVIH SHIKVIKTRK NKKDILNPDS SMETSPDFFF
Target Information
IFI16 (gamma-interferon-inducible protein 16) binds double-stranded DNA, preferentially to supercoiled and cruciform DNA structures.
It is involved in transcriptional regulation and acts as a transcriptional repressor. IFI16 may regulate hematopoietic differentiation by activating unknown target genes and controls cellular proliferation through modulation of p53/TP53 and retinoblastoma protein functions.
IFI16 also participates in innate immune responses by recognizing viral dsDNA in the cytosol and nucleus. Upon binding viral DNA, it recruits TMEM173/STING and induces IFN-beta expression.
Additionally, IFI16 activates the IFR3 signaling cascade during HSV-1 infection, promotes heterochromatin assembly on herpesviral DNA, and inhibits viral immediate-early gene expression and replication.
IFI16 is further implicated in MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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