Thermo Fisher Scientific CRACC Monoclonal Antibody (520914)
Flow Cytometry에 적합한 Mouse CRACC/SLAMF7 단클론 항체로, Rat IgG2a 아이소타입을 가짐. CHO 유래 재조합 단백질을 면역원으로 사용하며, 단백질 A/G로 정제됨. Lyophilized 형태로 제공되며, PBS + 5% trehalose buffer에 보관. 연구용으로만 사용 가능.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: 0.25 µg per million cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 520914 |
| Immunogen | CHO-derived recombinant mouse CRACC/SLAMF7 (Ala22–Gly224) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.5 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2606928 |
Product Specific Information
- In direct ELISAs, no cross-reactivity with recombinant human CRACC is observed.
- Reconstitute at 0.5 mg/mL in sterile PBS.
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway and may play a role in lymphocyte adhesion. Isoform 3 does not mediate activation.
SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea. Expression is detected in NK cells, activated B-cells, and NK-cell lines but not in promyelocytic, B-, or T-cell lines. Isoform 3 is expressed at a much lower level than isoform 1. There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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