Thermo Fisher Scientific CRACC Monoclonal Antibody (520914)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

0.25 µg per million cells

-

Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rat / IgG2a

Class

Monoclonal

Type

Antibody

Clone

520914

Immunogen

CHO-derived recombinant mouse CRACC/SLAMF7 Ala22-Gly224 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:CRACC (CD319),uniProtId:Q8BHK6-1,ncbiNodeId:10090,antigenRange:22-224,antigenLength:333,antigenImageFileName:MA5-24227_CRACC_CD319_Q8BHK6-1_Rat.svg,antigenImageFileNamePDP:MA5-24227_CRACC_CD319_Q8BHK6-1_Rat_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

0.5 mg/mL

Purification

Protein A/G

Storage buffer

PBS with 5% trehalose

Contains

No Preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2606928

Product Specific Information

In direct ELISAs, no cross-reactivity with recombinant human CRACC is observed.

Reconstitute at 0.5 mg/mL in sterile PBS.

Target Information

SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain. Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway. It may play a role in lymphocyte adhesion. Isoform 3 does not mediate any activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro). SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines. The isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.