Thermo Fisher Scientific ADAM23 Polyclonal Antibody
ADAM23 단백질을 인식하는 Thermo Fisher Scientific의 양친항체로, 인간 시료에 반응합니다. Western blot과 Immunoprecipitation에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 동결건조 형태로 제공되며, 뇌 조직 연구 및 세포 부착 관련 연구에 활용됩니다.
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- PA547678
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1 µg/mL |
| Immunoprecipitation (IP) | 25 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | CHO-derived recombinant human ADAM23 (Ser60–His585) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 5% trehalose |
| Contains | No Preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2610098 |
Product Specific Information
In direct ELISAs and Western blots, less than 5% cross-reactivity with recombinant human ADAM8, ADAM9, and ADAM22 is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Target Information
ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain), are a family of membrane-anchored proteins expressed in various tissues. They are involved in proteolysis, adhesion, fusion, and intracellular signaling.
ADAM23 is expressed exclusively in fetal and adult brain and may function as an integrin ligand in neural cells. Its disintegrin-like domain promotes adhesion of neuroblastoma and astrocytoma cells through interaction with αvβ3 integrin.
Unlike other metalloproteinases, ADAM23 lacks the catalytic histidine and glutamic acid residues, suggesting a role in cell adhesion rather than protease activity. Evidence also indicates ADAM23 may act as a tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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