Thermo Fisher Scientific KIM-1 Monoclonal Antibody (3A12E10)
인간 KIM-1 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, Flow cytometry, ELISA에 적합합니다. 단백질 G 정제, 1 mg/mL 농도, PBS 및 sodium azide 포함. 연구용으로만 사용.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3A12E10 |
| Immunogen | Purified recombinant fragment of human HAVCR1 (AA: 70–290) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090872 |
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail.
Its endogenous ligand is Tim-4. CD365 serves as a receptor or co-receptor for several viruses including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses, binding via phosphatidylserine exposed on viral envelopes.
Polymorphisms in the human CD365 gene (HAVCR1) are associated with infection susceptibility and disease severity. CD365 is also involved in T cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines.
A soluble form of CD365 can be generated by metalloproteinase-mediated proteolytic cleavage of the surface protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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