Thermo Fisher Scientific KIM-1 Monoclonal Antibody (3D9F5)
KIM-1 (CD365) 단백질을 인식하는 Mouse monoclonal antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 ELISA에 적합하며, Protein G로 정제된 1 mg/mL 액상 형태입니다. 4°C 또는 -20°C에서 보관 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1:10,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D9F5 |
| Immunogen | Purified recombinant fragment of human HAVCR1 (AA: 70–290) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3093320 |
Target Information
CD365, also known as T-cell immunoglobulin and mucin domain 1 (Tim-1), is a type I surface glycoprotein composed of an extracellular N-terminal immunoglobulin V-like domain, a mucin domain, and a short cytoplasmic tail. Its endogenous ligand is Tim-4. CD365 functions as a receptor or co-receptor for several viruses, including hepatitis A and C, Ebola, Marburg, Dengue, Zika, West Nile, and Japanese encephalitis viruses. Viral binding occurs via phosphatidylserine exposed on viral envelopes. Polymorphisms in the human CD365 gene (HAVCR1) are associated with susceptibility to infection and disease severity. CD365 is also involved in T-cell co-stimulation and is primarily expressed in epithelial cells, with high expression in A549, 769-P, and Caco-2 cell lines. A soluble form of CD365 can be generated by metalloproteinase-mediated proteolytic cleavage.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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