
Thermo Fisher Scientific PTH1R Polyclonal Antibody
Rabbit polyclonal antibody targeting human PTH1R; validated for IHC (Paraffin) at 2–4 µg/mL. High specificity via antigen affinity purification. Suitable for research on parathyroid hormone receptor signaling. For research use only.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 2–4 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic 20 amino acid peptide from N-terminal extracellular domain of human PTH1R |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2551484 |
Product Specific Information
Percent identity with other species by BLAST analysis:
Human, Monkey, Marmoset (100%)
Gorilla, Gibbon, Bovine, Pig (95%)
Orangutan, Elephant, Dog (90%)
Target Information
Parathyroid hormone receptor 1 (PTH1R) is a member of the G-protein coupled receptor family. It serves as a receptor for parathyroid hormone (PTH) and parathyroid hormone-like hormone (PTHLH). The receptor activity is mediated by G proteins that activate adenylyl cyclase and a phosphatidylinositol-calcium second messenger system.
Defects in this receptor are associated with Jansen’s metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), and enchondromatosis.
PTH1R expression has been reported in bone, breast, brain, colon, GI, kidney, liver, placenta, skin, umbilical cord, and uterus.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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