Thermo Fisher Scientific Embigin Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) [IHC (P)]

• Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

• Percent identity with other species by BLAST analysis:
  Human, Chimpanzee, Gorilla, Monkey (100%); Orangutan (94%); Gibbon, Marmoset, Bat (88%); Bovine, Dog (82%).
• For IHC(P), use heat-induced antigen retrieval in pH 6.0 citrate buffer.
  After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

Target Information

Embigin is a 327 amino acid regulatory protein belonging to the immunoglobulin superfamily class of CAMs, with two Ig-like (immunoglobulin-like) V-type domains.
In situ hybridization analysis shows that Embigin has specific carbohydrate epitopes and plays an important role in early postimplantation embryogenesis.
A highly glycosylated transmembrane glycoprotein, Embigin acts as a regulator of cell/ECM interactions during development and homeostasis of normal adult tissues.
Transfection studies suggest its role in promotion of integrin-mediated cell-substratum adhesion.
Widely expressed in most tissues and embryonal carcinoma cells, prostate and mammary cancer cell lines, it may also help in the classification of human carcinomas.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.