Thermo Fisher Scientific DAXX Monoclonal Antibody (CL3580)
인간 DAXX 단백질을 인식하는 Mouse monoclonal antibody(CL3580). IHC(P) 및 ICC/IF에 사용 가능하며, Protein A로 정제된 액상 형태. PBS(40% glycerol) buffer에 보관하며, 단기 4°C, 장기 -20°C 저장 권장.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Concentration: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | CL3580 |
| Immunogen | Recombinant protein corresponding to Human DAXX (UniProt ID: Q9UER7-1, antigen range: 47–182) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848919 |
Product Specific Information
Immunogen sequence:
ARGSSSSGGK KCYKLENEKL FEEFLELCKM QTADHPEVVP FLYNRQQRAH SLFLASAEFC NILSRVLSRA RSRPAKLYVY INELCTVLKA HSAKKKLNLA PAATTSNEPS GNNPPTHLSL DPTNAENTAS QSPRTR
Target Information
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and cytoplasm. It interacts with proteins such as apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it acts as a transcription repressor binding to sumoylated transcription factors, with repression relieved by sequestration into promyelocytic leukemia nuclear bodies or nucleoli. It also associates with centromeres in G2 phase and may regulate apoptosis in the cytoplasm. Subcellular localization and function are modulated by post-translational modifications, including sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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