Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (A1exF5), APC, eBioscience
인간 및 마우스 Arginase 1을 인식하는 단클론 항체로, APC 형광체가 결합되어 Flow Cytometry에 최적화됨. 세포 내 염색 프로토콜과 호환되며, 높은 특이성과 안정적인 신호 제공. 4°C 보관, 동결 금지.
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Thermo Fisher Scientific Arginase 1 Monoclonal Antibody (A1exF5), APC, eBioscience™
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Flow Cytometry (Flow) | 1.0 µg/test | View 28 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human, Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | A1exF5 |
| Immunogen | E.coli-derived recombinant mouse Arginase 1 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2734834 |
Additional Formats Available
- Alexa Fluor 488
- Alexa Fluor 700
- Brilliant UV 805
- Brilliant Violet 421
- Brilliant Violet 480
- Brilliant Violet 650
- Brilliant Violet 711
- eFluor 450
- PE
- PE-Cyanine7
- PerCP-eFluor 710
- Request custom conjugation
Product Specific Information
The monoclonal antibody A1exF5 recognizes both human and mouse Arginase 1 (Arg1), a cytosolic enzyme.
This clone is compatible with standard intracellular staining protocols and the Foxp3/Transcription Factor Staining Buffer Set.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on normal human peripheral blood cells using the Intracellular Fixation & Permeabilization Buffer Set (Product #88-8824-00) and standard protocols.
Refer to BestProtocols®: Protocol A for cytoplasmic intracellular proteins.
Recommended use ≤ 1.0 µg/test (100 µL final volume). Adjust cell number empirically (10⁵–10⁸ cells/test). Titrate for optimal performance.
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Target Information
Arginase-1 (Arg1) is a 35 kDa enzyme that converts L-arginine to urea and L-ornithine, completing the urea cycle.
Polyamines produced are essential for cell proliferation and detoxification.
Arginase 1 down-regulates nitric oxide production by depleting substrate for NO synthase.
Expressed in liver, neutrophils, myeloid-derived suppressor cells (MDSC), and neural stem cells in both human and mouse.
In humans, expression occurs in blood neutrophils but not CCR3+ granulocytes.
In mice, Arginase 1 marks alternatively activated macrophages (M2a).
Associated with myeloid cells infiltrating tumors and hepatocellular carcinomas.
Defects cause argininemia, an autosomal recessive disorder with hyperammonemia.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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