Thermo Fisher Scientific HEF1 Monoclonal Antibody (3F7A9)
인간 HEF1 단백질을 인식하는 Mouse IgG1 단클론 항체로, 다양한 분석법(WB, ICC/IF, Flow, ELISA)에 적합합니다. 고순도의 Protein G 정제 항체이며 액상 형태로 제공됩니다. 세포 신호전달 및 암 관련 연구용으로 최적화된 제품입니다.
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Applications and Tested Dilution
| Application | Tested Dilution Range |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3F7A9 |
| Immunogen | Purified recombinant fragment of human NEDD9 (AA: 82–398) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3090807 |
Target Information
HEF-1 is a multifunctional protein involved in integrin-based signaling that affects cell motility, growth, apoptosis, and oncogenic transformation. The Cas family of docking proteins are key regulators of these cellular processes and are substrates of focal adhesion kinase (FAK) and Src family tyrosine kinases, both of which are active targets in drug development. HEF1 overexpression increases levels of mRNA transcripts encoding proteins associated with motility and invasiveness, such as metalloproteinases, MLCK, p160ROCK, and ErbB1. It also mediates apoptosis in epithelial-derived cell lines (e.g., MCF7, HeLa). Clinical studies have shown that overexpression of BCAR1 (p130Cas), a related protein, is linked to tamoxifen resistance, emphasizing the importance of studying this protein family in cancer prognosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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