Thermo Fisher Scientific H3K14me2 Polyclonal Antibody
H3K14me2에 특이적인 Rabbit Polyclonal Antibody로, Western blot 및 Immunocytochemistry에 적합합니다. 인간 Di-Methyl-Histone H3의 Lys14 메틸화 부위를 인식하며, 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA5102714
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:20–1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic methylated peptide derived from human Di-Methyl-Histone H3 around the methylation site of Lys14 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815933 |
Product Specific Information
Antibody detects endogenous levels of Di-Methyl-Histone H3 only when methylated at Lys14.
Target Information
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3, along with four core histone proteins, binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication, and chromosomal stability.
Post-translationally, histones are modified in various ways to either directly change chromatin structure or allow for the binding of specific transcription factors.
The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several types of post-translational modifications that influence cellular processes. These include methylation or acetylation of lysine and arginine residues and phosphorylation of serine or threonine.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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