Thermo Fisher Scientific ZBTB5 Polyclonal Antibody
ZBTB5 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot과 IHC에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.02% sodium azide를 포함하며, 2–8°C 보관 권장.
- 카탈로그번호
- PA521085
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 16 amino acid peptide near the carboxy terminus of human ZBTB6 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long term storage, store at −20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153940 |
Product Specific Information
- Suggested positive control: mouse brain tissue lysate
- PA5-21085 can be used with blocking peptide PEP-1199
Target Information
The ZBTB family of proteins consists of diverse zinc finger proteins containing a BTB (BR-C, ttk, and bab) domain.
ZBTB5 was identified as a POZ domain Kruppel-like zinc finger (POK) protein. It binds DNA and represses transcription of the cell cycle arrest gene p21.
ZBTB5 interacts with co-repressor histone deacetylase complexes (BCoR, NCoR, SMRT) via its POZ domain, leading to histone deacetylation (Ac-H3, Ac-H4) at promoter regions.
It promotes cell proliferation and progression, suggesting a potential proto-oncogenic role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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