ELK Biotechnology KGP1 rabbit pAb
KGP1 단백질에 특이적인 rabbit polyclonal antibody로 WB 및 ELISA에 사용 가능. 인체 및 생쥐 시료에 반응. 세포질 및 세포막에 위치한 단백질 검출에 적합. -20°C에서 1년 보관 가능.
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제품명
KGP1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB, ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 73 kD |
| Gene ID (Human) | 5592 |
| Human Swiss-Prot No | Q13976 |
| Cellular Localization | Cytoplasm. Colocalized with TRPC7 in the plasma membrane. |
| Species Reactivity | Human, Mouse |
Background
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Iα, Iβ, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types.
The PRKG1 gene on human chromosome 10 encodes the soluble Iα and Iβ isoforms of PRKG by alternative transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II.
The PRKG1 proteins play a central role in regulating cardiovascular and neuronal functions in addition to relaxing smooth muscle tone, preventing platelet aggregation, and modulating cell growth.
This gene is most strongly expressed in all types of smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Iα and Iβ have identical cGMP-binding domains.
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