ELK Biotechnology RASA1 rabbit pAb
RASA1 단백질을 인식하는 토끼 다클론 항체로, WB 및 ELISA에 적합합니다. 세포질 내 RASA1 단백질 검출에 사용되며, 고농도(1 mg/ml)로 제공됩니다. -20°C에서 1년간 보관 가능합니다. 인간 및 랫트 시료에 반응합니다.
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RASA1 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | RASA1 rabbit pAb |
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Species Reactivity | Human; Rat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 115 kD |
| GeneID (Human) | 5921 |
| Human Swiss-Prot No. | P20936 |
| Cellular Localization | Cytoplasm |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation.
Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome.
Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed.
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