ELK Biotechnology ZDH17 rabbit pAb

ELK Biotechnology ZDH17 rabbit pAb

제품 정보

Background

• Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA
• Domain: The DHHC domain is required for palmitoyltransferase activity
• Function: Palmitoyltransferase specific for neuronal proteins (SNAP25, DLG4/PSD95, GAD2, SYT1, HD). Involved in sorting or targeting proteins for endocytosis initiation at the plasma membrane. May play a role in NF-kappa-B signaling pathway.
• Miscellaneous: Early pathology of Huntington’s disease is observed in medium spiny neurons projecting into the globus.
• Similarity: Belongs to DHHC palmitoyltransferase family, AKR/ZDHHC17 subfamily; contains 1 DHHC-type zinc finger and 5 ANK repeats.
• Subunit: Binds huntingtin (HD); interaction inversely correlated with polyglutamine tract length in Huntington disease.
• Tissue Specificity: Expressed in all brain regions; highest in cortex, cerebellum, occipital lobe, and caudate; lowest in spinal cord. Also expressed in testis, pancreas, heart, and kidney.