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ELK Biotechnology ZDH17 rabbit pAb
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ZDH17 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 사용 가능. 인간 및 생쥐 시료에 반응. 골지체 및 시냅스막 관련 단백질 연구에 적합. -20°C에서 1년 보관 가능.
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ELK Biotechnology ES10774-100UL ZDH17 rabbit pAb, 100UL pk판매 단위 pk ·
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402,000원VAT 포함 442,200원
ELK Biotechnology ES10774-50UL ZDH17 rabbit pAb, 50UL pk판매 단위 pk ·
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301,000원VAT 포함 331,100원
ELK Biotechnology · ELK Biotechnology ZDH17 rabbit pAb
ELK Biotechnology ZDH17 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ZDH17 rabbit pAb |
| Applications | WB, ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 69 kD |
| Gene ID (Human) | 23390 |
| Human Swiss-Prot No. | Q8IUH5 |
| Species Reactivity | Human, Mouse |
| Cellular Localization | Golgi apparatus membrane; multi-pass membrane protein. Cytoplasmic vesicle membrane; multi-pass membrane protein. Cell junction, synapse, presynaptic cell membrane; multi-pass membrane protein. Low extracellular Mg(2+) induces increase in Golgi and post-Golgi membrane vesicles. |
Background
- Catalytic activity: Palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA
- Domain: The DHHC domain is required for palmitoyltransferase activity
- Function: Palmitoyltransferase specific for neuronal proteins (SNAP25, DLG4/PSD95, GAD2, SYT1, HD). Involved in sorting or targeting proteins for endocytosis initiation at the plasma membrane. May play a role in NF-kappa-B signaling pathway.
- Miscellaneous: Early pathology of Huntington’s disease is observed in medium spiny neurons projecting into the globus.
- Similarity: Belongs to DHHC palmitoyltransferase family, AKR/ZDHHC17 subfamily; contains 1 DHHC-type zinc finger and 5 ANK repeats.
- Subunit: Binds huntingtin (HD); interaction inversely correlated with polyglutamine tract length in Huntington disease.
- Tissue Specificity: Expressed in all brain regions; highest in cortex, cerebellum, occipital lobe, and caudate; lowest in spinal cord. Also expressed in testis, pancreas, heart, and kidney.
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