ELK Biotechnology KBRS2 rabbit pAb
ELK Biotechnology의 KBRS2 rabbit pAb는 인간 및 마우스 시료에 반응하는 다클론 항체로, WB 및 ELISA에 적합합니다. 세포질에 위치한 KBRS2 단백질을 인식하며, NF-kappa-B 활성을 조절하는 연구에 활용됩니다. -20°C에서 1년 보관 가능합니다.
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제품명
KBRS2 rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Applications | WB; ELISA |
| Recommended Dilutions | WB 1:500–2000, ELISA 1:5000–20000 |
| Immunogen | Synthesized peptide derived from part region of human protein |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 21 kD |
| Gene ID (Human) | 28511 |
| Human Swiss-Prot No. | Q9NYR9 |
| Cellular Localization | Cytoplasm |
| Species Reactivity | Human; Mouse |
Background
In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and are therefore similar to the constitutively active forms of oncogenic Ras.
This suggests that members of this family are clearly different from other small GTPases.
Function:
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing degradation of NF-kappa-B inhibitor beta (NFKBIB). It may block phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Sequence caution:
Absence of residues from position 133 within an exon changes the frame, not due to alternative splicing.
Similarity:
Belongs to the small GTPase superfamily, Ras family, KappaB-Ras subfamily.
Subunit:
Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro, but likely only with NFKBIB in vivo.
Tissue specificity:
Widely expressed.
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