ELK Biotechnology WWTR1 rabbit pAb

제품명

WWTR1 rabbit pAb

공급업체

ELK Biotechnology

제품 정보

세포 내 위치 (Cellular Localization)

Nucleus, Cytoplasm, Cell membrane.
Concentrates along specific portions of the plasma membrane and accumulates in punctate nuclear bodies (By similarity).
When phosphorylated, retained in the cytoplasm by YWHAZ (By similarity).
Can be retained in the nucleus by MED15 (PubMed:18568018).
Localized in the cytoplasm in areas of epithelial cell high density (PubMed:21145499).
At blastocyst stage expressed in the nucleus in trophectodermal cells, however expressed in the cytoplasm in the inner cell mass (By similarity).

배경 정보 (Background)

• Domain: Binds to transcription factors via its WW domain.
• PDZ-binding motif: Essential for stimulated gene transcription; localizes the protein into both punctate nuclear foci and plasma membrane-associated complexes.
• Function: Acts as a transcriptional coactivator.
• PTM: Phosphorylated; phosphorylation inhibits transcriptional coactivation through YWHAZ-mediated nuclear export.
• Similarity: Contains 1 WW domain.
• Subcellular location: Concentrates along specific portions of the plasma membrane and accumulates in punctate nuclear bodies; retained in cytoplasm when phosphorylated.
• Subunit interaction: Binds to SLC9A3R2 via PDZ motif at plasma membrane; binds to YWHAZ in vivo and in vitro through phosphoserine-binding motif RSHSSP.
• Tissue specificity: Highly expressed in kidney, heart, placenta, and lung.