ELK Biotechnology TNNT3 rabbit pAb

제품명

TNNT3 rabbit pAb

제품 설명

TNNT3 단백질에 특이적으로 결합하는 토끼 폴리클로날 항체입니다. 근육 수축 과정에서 중요한 역할을 하는 트로포닌 복합체 연구에 유용합니다.

제품 정보

Background

The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction.
The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity.
There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein.