Thermo Fisher Scientific SHANK2 Polyclonal Antibody
SHANK2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC/IF 등에 적합하며, 인간과 생쥐 시료에 반응합니다. 고순도 Affinity chromatography 정제, 안정적인 PBS/glycerol 저장용액 구성.
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- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human SHANK2 (Accession Q9UPX8), corresponding to amino acid residues P555–M605 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2851317 |
Product Specific Information
Antibody detects endogenous levels of total SHANK2.
Target Information
This gene encodes a protein that is a member of the Shank family of synaptic proteins, functioning as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats and an SH3 domain. This family member includes a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides, and a sterile alpha motif.
Alternative splicing in Shank genes regulates molecular structure and interactions in postsynaptic densities of the adult and developing brain. Alterations in SHANK2 may be associated with susceptibility to autism spectrum disorder. Multiple transcript variants exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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