Thermo Fisher Scientific HECT domain of NEDD4 Polyclonal Antibody
NEDD4 단백질의 HECT 도메인을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot 및 IHC에 사용 가능하며 사람, 생쥐, 랫드 반응성. 동결건조 형태로 제공되며 연구용으로만 사용.
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Thermo Fisher Scientific HECT domain of NEDD4 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300–1:2,000 |
| Immunohistochemistry (IHC) | 1:300–1:2,000 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the HECT domain of human NEDD4 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- The peptide is homologous in rat and mouse.
- Specificity: NEDD4.
Target Information
The E3 ubiquitin-protein ligase NEDD4 is a Ubl conjugation pathway protein containing one HECT (E6AP-type E3 ubiquitin-protein ligase) domain and four WW domains.
It is involved in the degradation pathway of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity.
Acts as a potential proto-oncogene that negatively regulates PTEN via ubiquitination, analogous to Mdm2 and p53.
Also involved in viral budding and regulation of epithelial Na⁺ channels, contributing to arterial hypertension.
NEDD4 protein localizes to the sarcolemmal region of muscle fibers. Increased expression is associated with unloaded and denervated muscles and decreased Notch1 expression, acting as a down regulator of Notch-1 gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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