Thermo Scientific™

CellSensor™ ISRE-bla HEK293T Cell Line

Interferon cell signaling is a critical pathway involved in viral defense and autoimmune disease. The CellSensor™ ISRE-bla HEK 293T cell자세히 알아보기

Interferon cell signaling is a critical pathway involved in viral defense and autoimmune disease. The CellSensor™ ISRE-bla HEK 293T cell line is responsive to interferon alpha and can be used to probe the JAK/STAT signaling pathway. The CellSensor™ ISRE-bla HEK 293T cell line contains the β-lactamase reporter gene under the control of the interferon stimulated response element (ISRE). This cell line was engineered by transduction of the ISRE-bla construct into HEK 293T cells by lentivirus. Flow cytometry was then used to isolate a pool of clones responsive to interferon alpha a stimulation. A dose response curve for this assay against interferon alpha is available in the validation packet. Academic and non-profit customers, please inquire for special pricing.

사양

어세이 입력Cell-based beta lactamase reporter gene

셀 상태Dividing Cells

제품라인CellSensor™

수량1 Vial

타겟 입력JAK/STAT (Type I IFN) pathway, TYK2, JAK1

System TypeCellSensor™

Druggable TargetSignaling Pathway

Unit SizeEach