ELK Biotechnology ALK (phospho-Tyr1078) rabbit pAb

제품명

ALK (phospho-Tyr1078) rabbit pAb

기본 정보

세포 내 위치

Cell membrane; Single-pass type I membrane protein.
Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

배경 정보

This gene encodes a receptor tyrosine kinase belonging to the insulin receptor superfamily.
It consists of an extracellular domain, a single-pass transmembrane region, and an intracellular kinase domain.
ALK plays an important role in brain development and affects specific neurons in the nervous system.
Alterations such as rearrangement, mutation, or amplification are found in several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often create fusion genes such as ALK/EML4, ALK/RANBP2, ALK/ATIC, ALK/TFG, ALK/NPM1, and ALK/SQSTM1.

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