ELK Biotechnology ALK (phospho-Tyr1078) rabbit pAb
ALK (phospho-Tyr1078) rabbit polyclonal antibody로 인간, 생쥐, 랫트에 반응하며 WB에 적합합니다. 신경계 발달 및 종양 관련 ALK 단백질 인산화 상태 분석에 유용합니다. 고순도 IgG, 1 mg/ml 농도, -20°C에서 1년 안정적으로 보관 가능합니다.
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제품명
ALK (phospho-Tyr1078) rabbit pAb
기본 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | ALK tyrosine kinase receptor (EC 2.7.10.1), Anaplastic lymphoma kinase, CD antigen CD246 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human ALK (Tyr1078) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 150–240 kD |
| GeneID (Human) | 238 |
| Human Swiss-Prot No | Q9UM73 |
| Species Reactivity | Human, Rat, Mouse |
세포 내 위치
Cell membrane; Single-pass type I membrane protein.
Membrane attachment is essential for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
배경 정보
This gene encodes a receptor tyrosine kinase belonging to the insulin receptor superfamily.
It consists of an extracellular domain, a single-pass transmembrane region, and an intracellular kinase domain.
ALK plays an important role in brain development and affects specific neurons in the nervous system.
Alterations such as rearrangement, mutation, or amplification are found in several tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often create fusion genes such as ALK/EML4, ALK/RANBP2, ALK/ATIC, ALK/TFG, ALK/NPM1, and ALK/SQSTM1.
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