ELK Biotechnology Bim (phospho-Ser77) rabbit pAb
Bim 단백질의 Ser77 인산화 부위를 인식하는 rabbit polyclonal antibody로, WB에 적합합니다. 인간 및 마우스 시료에 반응하며, 세포 내막계 및 미토콘드리아에 위치한 Bim 단백질 검출에 유용합니다. -20°C에서 1년 보관 가능합니다.
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제품명
Bim (phospho-Ser77) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | Bcl-2-like protein 11 (Bcl2-L-11), Bcl2-interacting mediator of cell death |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human Bim (Ser77) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 22 kDa |
| Gene ID (Human) | 10018 |
| Human Swiss-Prot No. | O43521 |
| Species Reactivity | Human, Mouse |
세포 내 위치 (Cellular Localization)
Endomembrane system; Peripheral membrane protein associated with intracytoplasmic membranes.
- Isoform BimEL: Mitochondrion. Translocates from microtubules to mitochondria on loss of cell adherence.
- Isoform BimL: Mitochondrion.
- Isoform BimS: Mitochondrion.
- Isoform Bim-alpha1: Mitochondrion.
Background
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators involved in various cellular activities.
This protein contains a Bcl-2 homology domain 3 (BH3) and acts as an apoptotic activator through interactions with other BCL-2 family members.
Expression can be induced by nerve growth factor (NGF) and the forkhead transcription factor FKHR-L1, suggesting a role in neuronal and lymphocyte apoptosis.
Transgenic mouse studies indicate this gene functions as an essential initiator of apoptosis in thymocyte-negative selection.
Several alternatively spliced transcript variants have been identified.
[provided by RefSeq, Jun 2013]
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