ELK Biotechnology AMPKα1 (phospho-Ser485) rabbit pAb
AMPKα1 (phospho-Ser485) rabbit pAb는 AMPK 활성 조절 연구에 적합한 인산화 특이 항체입니다. WB에서 사용 가능하며, 사람, 마우스, 랫트에 반응합니다. 세포 내 에너지 대사 및 스트레스 반응 연구에 유용합니다. -20°C에서 1년 보관 가능합니다.
- 판매단위
- pk
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제품명
AMPKα1 (phospho-Ser485) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1), Acetyl-CoA carboxylase kinase (ACACA kinase) (EC 2.7.11.27), Hydroxymethylglutaryl-CoA reductase kinase (HMGCR kinase) (EC 2.7.11.31), Tau-protein kinase PRKAA1 (EC 2.7.11.26) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human AMPKα1 (Ser485) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 65 kDa |
| Gene ID (Human) | 5562 |
| Human Swiss-Prot No. | Q13131 |
| Cellular Localization | Cytoplasm, Nucleus. In response to stress, recruited by p53/TP53 to specific promoters. |
| Species Reactivity | Human, Mouse, Rat |
Background
The protein encoded by this gene belongs to the serine/threonine protein kinase family and serves as the catalytic subunit of the 5'-AMP-activated protein kinase (AMPK). AMPK acts as a cellular energy sensor conserved across eukaryotic cells. Its kinase activity is activated by stimuli that increase the cellular AMP/ATP ratio, regulating key metabolic enzymes through phosphorylation. It protects cells from ATP depletion by turning off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
[Provided by RefSeq, Jul 2008]
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