ELK Biotechnology BAP1 (phospho-Ser592) rabbit pAb
BAP1 단백질의 Ser592 인산화 형태를 인식하는 rabbit polyclonal antibody. WB에 적합하며 1:1000–2000 희석 권장. 세포 내 주로 핵에 위치하며, 암 관련 연구 및 단백질 탈유비퀴틴화 연구에 활용 가능.
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제품 개요
제품명: BAP1 (phospho-Ser592) rabbit pAb
공급업체: ELK Biotechnology
BAP1 단백질의 Ser592 인산화 부위를 특이적으로 인식하는 rabbit polyclonal antibody입니다. 세포 내 주로 핵에 존재하며, 암 억제 및 탈유비퀴틴화 효소 관련 연구에 유용합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | BAP1 (phospho-Ser592) rabbit pAb |
| Alternative Names | Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12); BRCA1-associated protein 1; Cerebral protein 6 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human BAP1 (Ser592) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 80 kD |
| GeneID (Human) | 8314 |
| Human Swiss-Prot No | Q92560 |
| Cellular localization | Cytoplasm, Nucleus (mainly nuclear). Binds to chromatin. Localizes to cytoplasm when monoubiquitinated by UBE2O (PubMed:24703950). |
| Species Reactivity | Human, Rat, Mouse |
Background
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. It may be involved in regulation of transcription, cell cycle and growth, response to DNA damage, and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma, and cutaneous melanoma. [provided by RefSeq, May 2013]
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