ELK Biotechnology AS160 (phospho-Ser318) rabbit pAb
AS160 (phospho-Ser318) rabbit polyclonal antibody for WB detection; recognizes phosphorylated AS160 involved in insulin-regulated GLUT4 trafficking; suitable for human, rat, and mouse samples; stored at -20°C for long-term stability.
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제품명
AS160 (phospho-Ser318) rabbit pAb
제품 개요
AS160 (TBC1D4)는 Rab-GTPase-activating protein으로, 인슐린 의존적 GLUT4 수송 조절에 중요한 역할을 하는 단백질입니다. 본 항체는 인간 AS160의 Ser318 부위에 대한 인산화 펩타이드로부터 제작된 rabbit polyclonal antibody로, 인슐린 신호전달 및 포도당 항상성 연구에 적합합니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | AS160 (phospho-Ser318) rabbit pAb |
| Alternative Names | TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160) |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human AS160 (Ser318) |
| Species Reactivity | Human, Rat, Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 145 kDa |
| GeneID (Human) | 9882 |
| Human Swiss-Prot No | O60343 |
| Cellular Localization | Cytoplasm. Isoform 2 shows cytoplasmic perinuclear localization in myoblastic cells under resting and insulin-stimulated conditions. |
| Storage | -20°C / 1 year |
| Host | Rabbit |
Background
This gene belongs to the Tre-2/BUB2/CDC16 domain family. The encoded protein contains two phosphotyrosine-binding domains (PTB1, PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. It regulates insulin-dependent trafficking of the glucose transporter 4 (GLUT4), facilitating glucose uptake into skeletal muscle and adipose tissues. Reduced expression increases GLUT4 at the plasma membrane, indicating its role in intracellular retention under basal conditions. Upon insulin stimulation, AS160 becomes phosphorylated, dissociates from GLUT4 vesicles, increasing GLUT4 surface expression and enhancing glucose transport.
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