ELK Biotechnology APP (phospho-Thr668) rabbit pAb
APP 단백질의 Thr668 인산화 형태를 인식하는 토끼 다클론 항체. Western blot에 적합하며, 인간, 생쥐, 랫트 시료에서 반응. 알츠하이머 관련 단백질 연구에 활용 가능. -20°C에서 1년 보관 가능.
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APP (phospho-Thr668) Rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Product Name | APP (phospho-Thr668) rabbit pAb |
| Alternative Names | Amyloid beta A4 protein (ABPP), APPI, APP, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide (CVAP), PreA4, Protease nexin-II (PN-II) Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99; Beta-amyloid protein 42 (Beta-APP42); Beta-amyloid protein 40 (Beta-APP40); C83; P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (AICD-59, AID(59)); Gamma-secretase C-terminal fragment 57 (AICD-57, AID(57)); Gamma-secretase C-terminal fragment 50 (AICD-50, AID(50)); C31 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human APP (Thr668) |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 87 kDa |
| Gene ID (Human) | 351 |
| Human Swiss-Prot No. | P05067 |
| Species Reactivity | Human, Mouse, Rat |
| Storage | -20°C / 1 year |
세포 내 위치 (Cellular Localization)
Cell membrane; single-pass type I membrane protein. Found in perikaryon, growth cone, clathrin-coated pits, early endosome, and cytoplasmic vesicles.
Most APP is localized in intracellular vesicles with only a minor proportion at the cell surface.
During maturation, immature APP (N-glycosylated in the endoplasmic reticulum) moves to the Golgi complex for complete maturation (O-glycosylation and sulfation). After α-secretase cleavage, soluble APP is released extracellularly, and the C-terminal fragment is internalized to endosomes and lysosomes. Some APP accumulates in secretory transport vesicles. (PubMed:20580937)
배경 (Background)
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form several peptides.
Some peptides are secreted and interact with the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the amyloid plaques characteristic of Alzheimer’s disease.
Certain peptides exhibit antimicrobial activity against bacteria and fungi.
Mutations in this gene are associated with autosomal dominant Alzheimer’s disease and cerebral amyloid angiopathy.
Multiple transcript variants encoding different isoforms have been identified (RefSeq, Aug 2014).
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