ELK Biotechnology ASK1 (phospho-Thr845) rabbit pAb
ASK1 (phospho-Thr845) rabbit pAb은 인간, 랫, 마우스에 반응하는 폴리클로날 항체로, WB 분석에 적합합니다. 세포 내 MAPK 신호전달 연구에 활용되며, 고순도 IgG 형태로 -20°C에서 1년간 안정적으로 보관 가능합니다.
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다ELK Biotechnology · ELK Biotechnology ASK1 (phospho-Thr845) rabbit pAb
ASK1 (phospho-Thr845) rabbit pAb
제품 개요
ASK1 (phospho-Thr845) rabbit pAb은 인간 ASK1 단백질의 Thr845 인산화 부위를 인식하는 폴리클로날 항체입니다. MAPK/ERK 신호전달 경로 연구 및 세포 내 스트레스 반응 관련 단백질 분석에 활용됩니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | ASK1 (phospho-Thr845) rabbit pAb |
| Alternative Names | Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.11.25), Apoptosis signal-regulating kinase 1 (ASK-1), MAPK/ERK kinase kinase 5 (MEK kinase 5), MEKK 5 |
| Applications | WB |
| Recommended Dilutions | WB 1:1000–2000 |
| Immunogen | Synthesized phospho peptide around human ASK1 (Thr845) |
| Species Reactivity | Human, Rat, Mouse |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 155 kDa |
| GeneID (Human) | 4217 |
| Human Swiss-Prot No. | Q99683 |
| Storage | -20°C / 1 year |
| Host | Rabbit |
| Cellular Localization | Cytoplasm, Endoplasmic reticulum. Interaction with 14-3-3 proteins alters the distribution of MAP3K5/ASK1 and restricts it to the perinuclear endoplasmic reticulum region. |
Background
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK).
MAPKKK5 phosphorylates and activates its downstream kinase MKK4, which subsequently activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK).
MAPKKK5 is abundantly expressed in human heart and pancreas, and does not activate MAPK/ERK.
This conserved signaling pathway plays a key role in stress and apoptosis regulation across species from yeast to mammals.
ELK Biotechnology 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.