Thermo Fisher Scientific ACE2/Angiotensin I Converting Enzyme 2 Monoclonal Antibody (ACE2/7203)
인간 ACE2 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 및 ELISA에 사용 가능. 단백질 A/G 정제, 액상 형태, 200 µg/mL 농도. 심장, 신장, 고환 등에서 발현되는 ACE2 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
| ELISA | 2–4 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ACE2/7203 |
| Immunogen | Recombinant fragment (around aa1–300) of human ACE2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Heart, human kidney, testis, or small intestine
- Cellular Location: Cell membrane, secreted
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. Unlike its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. ACE2 also functions as a receptor for the SARS coronavirus. It converts the inactive vasoconstrictor angiotensin I (AngI) to Ang1–9 and the active form AngII to Ang1–7, differing from ACE which converts AngI to AngII. Lack of ACE2 expression in knockout mice leads to reduced cardiac contractility, highlighting its importance in heart function regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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