Thermo Fisher Scientific TGM2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 299-548 of human Transglutaminase 2 (TGM2) (NP_9451891) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TGM2,uniProtId:P21980-1,ncbiNodeId:9606,antigenRange:299-548,antigenLength:687,antigenImageFileName:PA5-87544_TGM2_P21980-1_Rabbit.svg,antigenImageFileNamePDP:PA5-87544_TGM2_P21980-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.73 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2804241

Product Specific Information

Positive Samples: SW480, A-549, DU145, PC-3

Immunogen sequence: TNYNSAHDQN SNLLIEYFRN EFGEIQGDKS EMIWNFHCWV ESWMTRPDLQ PGYEGWQALD PTPQEKSEGT YCCGPVPVRA IKEGDLSTKY DAPFVFAEVN ADVVDWIQQD DGSVHKSINR SLIVGLKIST KSVGRDERED ITHTYKYPEG SSEEREAFTR ANHLNKLAEK EETGMAMRIR VGQSMNMGSD FDVFAHITNN TAEEYVCRLL LCARTVSYNG ILGPECGTKY LLNLNLEPFS GKALCSWSIC

Target Information

Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer`s disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.