Thermo Fisher Scientific SFPQ Recombinant Rabbit Monoclonal Antibody (JU33-99)
SFPQ 단백질을 인식하는 토끼 유래 재조합 단클론 항체. WB, IHC, ICC/IF에 적합하며 다양한 조직에서 발현 확인 가능. Alzheimer’s disease 등 신경퇴행 질환 연구에 유용. 단백질 A 정제, 액상 형태로 -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JU33-99 |
| Immunogen | Synthetic peptide within Human SFPQ aa 658–707 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles, store in dark |
| Shipping Conditions | Wet ice |
| RRID | AB_2848556 |
Product Specific Information
Positive Control: K562, Daudi, mouse testis tissue, mouse lung tissue lysate, rat brain tissue, human tonsil tissue, human liver cancer tissue, human kidney tissue.
Target Information
SFPQ (also named PSF) encodes a nuclear factor involved in RNA splicing and gene expression regulation. It forms a heteromer with NONO and participates in DNA pairing and repair. SFPQ has been identified as a downstream target of tau, showing nuclear depletion and cytoplasmic accumulation in neurons and astrocytes of Alzheimer’s disease brains. Reduced SFPQ levels may correlate with tau pathology, suggesting its important role in neurodegenerative diseases including AD. The SFPQ protein may appear as 47 kDa, 52 kDa, or 100 kDa forms in various cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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