Thermo Fisher Scientific MYOZ1 Monoclonal Antibody (OTI4C2), TrueMAB
MYOZ1 단백질을 표적하는 단클론 항체로, Western blot 및 IHC(P)에서 검증됨. Human, Mouse, Rat 반응성. Lyophilized 형태, PBS buffer에 보존. 연구용으로 사용되며, 근육 단백질 티틴 관련 연구에 적합.
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Thermo Fisher Scientific MYOZ1 Monoclonal Antibody (OTI4C2), TrueMAB
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4C2 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 106–299 of human MYOZ1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
Sarcomere assembly is regulated by the muscle protein titin, a giant elastic protein with kinase activity that extends half the length of a sarcomere. Titin acts as a scaffold for myofibrils and other muscle-related proteins.
MYOZ1 encodes a protein found in striated and cardiac muscle that binds to the titin Z1–Z2 domains and is a substrate of titin kinase, interactions critical to sarcomere assembly.
Mutations in MYOZ1 are associated with limb-girdle muscular dystrophy type 2G.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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