Thermo Fisher Scientific Cathepsin L Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.5–2 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 5–20 µg/mL

Product Specifications

Target Information

The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and myocardial ischemia, and in the renal tubular response to proteinuria. This protein, a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains produced from a single protein precursor. At least two transcript variants encoding the same protein have been identified for this gene.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.