Thermo Fisher Scientific COMT Polyclonal Antibody
Rabbit polyclonal antibody targeting Catechol-O-Methyltransferase (COMT). Validated for WB, IHC(P), and ICC/IF. High specificity and sensitivity with recombinant protein immunogen. Supplied as liquid, 500 µg/mL, stored at -20°C.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5–20 µg/mL |
| Immunocytochemistry (ICC/IF) | 5–20 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein Catechol-O-Methyltransferase (amino acids 52–271) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 500 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | –20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2903511 |
Target Information
Catechol-O-methyltransferase (COMT) catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including dopamine, epinephrine, and norepinephrine. This O-methylation is a major degradative pathway for catecholamine neurotransmitters.
COMT also plays a key role in metabolizing catechol drugs used for hypertension, asthma, and Parkinson’s disease.
It exists in two forms: a soluble form (S-COMT) and a membrane-bound form (MB-COMT), differing at the N-terminus. Multiple transcript variants arise through alternative translation initiation sites and promoters.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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