Thermo Fisher Scientific Phospho-Btk (Tyr551) Recombinant Rabbit Monoclonal Antibody (BtkY551-G12), Biotin
BTK 단백질의 Tyr551 인산화 부위를 인식하는 재조합 토끼 단클론 항체입니다. Flow Cytometry 및 ELISA에 사용 가능하며, Biotin으로 표지되어 있습니다. 인간 시료에 반응하며 Protein A/G로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Flow Cytometry (Flow) | 1–1,000 ng/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BtkY551-G12 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding human Btk (Y551). |
| Conjugate | Biotin |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897394 |
Additional Formats
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders. It interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which are critical molecules in both innate and adaptive immunity. BTK also interacts with key proteins involved in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting a role in lipopolysaccharide signal transduction.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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