Thermo Fisher Scientific RET Monoclonal Antibody (OTI21H5), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, we recommend adding 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
To use this carrier-free antibody for conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The receptor tyrosine kinase RET belongs to the cadherin superfamily and plays an essential role in neural crest development. RET can undergo oncogenic activation through cytogenetic rearrangement and transduces signals for cell growth and differentiation.
Mutations in the RET gene are linked to multiple endocrine neoplasia types IIA and IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding distinct isoforms have been identified, with additional variants of uncertain biological validity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.