Thermo Fisher Scientific Pannexin 3 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.2–1 µg/mL

Product Specifications

Product Specific Information

Peptide sequence:
IISELDKSYN RSIRLVQHML KIRQKSSDPY VFWNELEKAR KERYFEFPLL

Sequence homology:
Cow: 93%
Dog: 100%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 100%
Rabbit: 100%
Rat: 100%
Zebrafish: 86%

Target Information

Pannexins constitute a new family of gap junction type proteins. They are highly conserved in worms, mollusks, insects, and mammals, and are predicted to have four transmembrane regions, two extracellular loops, one intracellular loop, and intracellular N- and C-termini.

Besides the connexin proteins, Pannexin 1 and 2 seem to be molecular components of neuronal gap junctions (“electrical synapses”) that form connections between principal cells in the hippocampus. Functional expression in paired Xenopus oocytes indicated that pannexins can form communicating junctions.

In addition to forming gap junction channels in paired oocytes, Pannexin 1 can also form a mechanosensitive and ATP-permeable channel in the nonjunctional plasma membrane. Pannexin 1 and 3 are both glycoproteins with a cell surface distribution profile and life cycle dynamics distinct from connexin 43.

Pannexin 3 expression is prevalent in skin and cartilage. In transiently expressing cells, both pannexin 1 and 3 are incapable of forming intercellular channels but assemble into functional cell surface channels. Suggested roles in ischemic neuronal death, schizophrenia, inflammation, and tumor suppression highlight the biological significance of pannexins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.